Revisiting the Mongolian Gerbil Model for Hepatitis E Virus by Reverse Genetics

• DOI: 10.1128/spectrum.02193-21
• Publication Date: 2022-03-01T20:01:50Z
• Authors: Ling-Dong Xu; Fei Zhang; Chu Chen; Lei Peng; Wen-Ting Luo; Ruiai Chen; Pinglong Xu; Yao-Wei Huang
• Keywords: Mongolian gerbil; 0303 health sciences; Swine; Liver Neoplasms; interferon; Microbiology; Antiviral Agents; QR1-502; Reverse Genetics; Hepatitis E; 3. Good health; reverse genetics; 03 medical and health sciences; antivirals; hepatitis E virus (HEV); Hepatitis E virus; Animals; Humans; RNA; Gerbillinae; innate immunity; Research Article

HEV infects >20 million people annually, causing acute viral hepatitis as well as chronic hepatitis, neurological diseases, and pregnancy-associated high mortality, which require therapeutic intervention. The HEV antiviral research is largely limited by the lack of a convenient small animal model.