Screening of the Medicines for Malaria Venture Pandemic Response Box for Discovery of Antivirulent Drug against Pseudomonas aeruginosa

• DOI: 10.1128/spectrum.02232-22
• Publication Date: 2022-10-27T14:04:04Z
• Authors: Markéta Macho; Subhasish Saha; Grzegorz Konert; Avik Banerjee; Daniela Ewe; Pavel Hrouzek; Petra Urajová; Kumar Saurav
• Keywords: 0303 health sciences; Virulence Factors; Quorum Sensing; Observation; antivirulence activity; Pandemic Response Box; Microbiology; QR1-502; Anti-Bacterial Agents; 3. Good health; 03 medical and health sciences; quorum sensing inhibition; biofilm inhibition; Biofilms; Pseudomonas aeruginosa; Pandemics

The rise of drug-resistant pathogens as well as overuse and misuse of antibiotics threatens modern medicine as the number of effective antimicrobial drugs steadily decreases. Given the nature of antimicrobial resistance development under intense selective pressure such as the one posed by pathogen-eliminating antibiotics, new treatment options which could slow down the emergence of resistance are urgently needed.