Increased Abundance of Achromobacter xylosoxidans and Bacillus cereus in Upper Airway Transcriptionally Active Microbiome of COVID-19 Mortality Patients Indicates Role of Co-Infections in Disease Severity and Outcome

• DOI: 10.1128/spectrum.02311-21
• Publication Date: 2022-05-17T13:00:25Z
• Authors: Priti Devi; Ranjeet Maurya; Priyanka Mehta; Uzma Shamim; Aanchal Yadav; Partha Chattopadhyay; Akshay Kanakan; Kriti Khare; Janani Srinivasa ...; Shweta Sahni; Pallavi Mishra; Akansha Tyagi; Sujeet Jha; Sandeep Budhiraja; Bansidhar Tarai; Rajesh Pandey
• Keywords: 0301 basic medicine; pathogen genomics; Coinfection; SARS-CoV-2; Microbiota; COVID-19; nasopharyngeal RNA; Microbiology; Severity of Illness Index; QR1-502; 3. Good health; 03 medical and health sciences; co-infection; Bacillus cereus; Achromobacter denitrificans; host-pathogen interactions; disease sub-phenotype; Humans; Prospective Studies; Phylogeny; Research Article

COVID-19 is invariably a disease of diverse clinical manifestation, with multiple facets involved in modulating the progression and outcome. In this regard, we investigated the role of transcriptionally active microbial co-infections as possible modulators of disease pathology in hospital admitted SARS-CoV-2 infected patients.