Host Cell Oxidative Stress Induces Dormant Staphylococcus aureus Persisters

• DOI: 10.1128/spectrum.02313-21
• Publication Date: 2022-02-23T21:34:14Z
• Authors: Frédéric Peyrusson; Tiep Khac Nguyen; Tome Najdovski; Françoise Van Bam...
• Keywords: Multidrug tolerance

By their capacity to survive antibiotic pressure and regrow give rise a susceptible population once this is relieved, intracellular persisters of S. aureus may contribute explain therapeutic failures recurrent infections. Here, we show that the level dormancy subsequent resuscitate from resting state are dependent on oxidative stress in host cells where bacteria survive.