Outpatient Antibiotic Resistance Patterns of Escherichia coli Urinary Isolates Differ by Specialty Type

• DOI: 10.1128/spectrum.02373-21
• Publication Date: 2022-06-21T13:01:42Z
• Authors: Lauren Frisbie; Scott J. Weissman; Hema Kapoor; Marisa D’Angeli; Ann Salm; Jeff Radcliff; Peter Rabinowitz
• Keywords: Specialty; Antibiotic Stewardship; Outpatient clinic

Antibiotic-resistant E. coli infections represent a major cause of morbidity and mortality pose challenge to antibiotic stewardship. We analyzed large outpatient data set urinary isolates determine whether resistance patterns vary between types practices. Using deidentified from clinical reference laboratory over 5 years logistic regression, we examined the association with practice type, controlling for testing year, patient sex, age. The odds were significantly higher in urology/nephrology practices ampicillin (odds ratio [OR] 1.36; 95% CI, 1.10 1.69), ciprofloxacin (OR 2.29; 1.77 2.94), trimethoprim-sulfamethoxazole 1.52; 1.18 1.94), gentamicin 1.72; 1.16 2.46). Odds also oncology 1.54; 1.08 2.15) "all other specialties" 1.33; 1.13 1.56). In contrast, specimens obstetrics gynecology had lower having 0.90; 0.82 0.99) trimethoprim-sulfa 0.83; 0.73 0.93) but nitrofurantoin 1.03 1.70). Other findings included pediatric 0.78; 0.64 0.94) internal medicine 0.66; 0.51 0.84) (all P < 0.05). IMPORTANCE Patterns can specialties. use create specialty-specific antibiograms settings may improve