A Novel Approach To Identify Inhibitors of Iron Acquisition Systems of Pseudomonas aeruginosa

• DOI: 10.1128/spectrum.02437-22
• Publication Date: 2022-09-13T13:00:43Z
• Authors: Mamie Kannon; N. Miranda Nebane; Pedro Ruiz; Sara McKellip; Paige N. Vinson; Avishek Mitra
• Keywords: development of treatments and therapeutic interventions; 0301 basic medicine; Iron; oxyquinoline; Siderophores; high throughput; Heme; pharmaceuticals; heme transport; infectious diseases; Microbiology; whole cell; lung; drug discovery; cystic fibrosis; 03 medical and health sciences; iron; Bacterial Proteins; meropenem; heme; high-throughput screen; iron acquisition; siderophores; ferrous; iron acquisition inhibitor; raloxifene hydrochloride; rare diseases; econazole; Meropenem; vaccine related; Oxyquinoline; infection; QR1-502; 3. Good health; inhibitor; bacterial proteins; Raloxifene Hydrochloride; Pseudomonas aeruginosa; Econazole; Research Article

Since acquiring iron is paramount to P. aeruginosa ’s survival and colonization in the human host, developing novel strategies block access of host will allow us starve it an essential nutrient. uses siderophore, heme, or ferrous uptake systems acquire host. We have developed a approach through which we can directly identify molecules that prevent from utilizing heme iron.