Chromosome-Level Genome Sequences, Comparative Genomic Analyses, and Secondary-Metabolite Biosynthesis Evaluation of the Medicinal Edible Mushroom Laetiporus sulphureus

• DOI: 10.1128/spectrum.02439-22
• Publication Date: 2022-10-06T14:01:22Z
• Authors: Wei-ge Dong; Zhen-xin Wang; Xi-long Feng; Rui-qi Zhang; Dao-yin Shen; Shuangtian Du; Jin-ming Gao; Jianzhao Qi
• Keywords: 0301 basic medicine; Biological Products; Analgesics; biosynthetic potential; Terpenes; Basidiomycota; near-chromosome level assembly; Carbohydrates; secondary metabolite; Genomics; Microbiology; QR1-502; Chromosomes; Triterpenes; 3. Good health; 03 medical and health sciences; Cough; Polyketides; Rheumatic Diseases; Laetiporus sulphureus; pharmaceutical edible mushroom; Agaricales; Cellulose; Research Article

L. sulphureus is a parasitic basidiomycete fungus that causes brown rot. The fruiting bodies of L. sulphureus are used as ancient medicines in China and Europe to cure cancer, analgesia, cough, and rheumatism and are considered a functional food that regulates the body and improves health. L. sulphureus was inferred to be a tetrapolar system based on a high-quality genome, which will aid molecular breeding and artificial farming.