A Comparison of Host Responses to Infection with Wild-Type Avian Influenza Viruses in Chickens and Tufted Ducks

• DOI: 10.1128/spectrum.02586-22
• Publication Date: 2023-06-26T14:01:58Z
• Authors: Mahmoud M. Naguib; Per Eriksson; Elinor Jax; Michelle Wille; Cecilia Lindskog; Caroline Bröjer; Janina Krambrich; Jonas Waldenström; Robert H. S. Kraus; Göran Larson; Åke Lundkvist; Björn Olsen; Josef D. Järhult; Patrik Ellström
• Keywords: Infectious Medicine; Infektionsmedicin; Microbiology; influenza virus; QR1-502; Immunity, Innate; 3. Good health; Mikrobiologi; Ducks; Influenza in Birds; gene expression; Influenza A Virus, H9N2 Subtype; Humans; Animals; innate immunity; adaptive viral mutations; Chickens; Research Article

Our current findings highlight important aspects of IAV infection in birds that have implications for our understanding of its zoonotic ecology. In contrast to mallards where the intestinal tract is the main site of IAV replication, chickens and tufted ducks show limited or no signs of intestinal infection suggesting that the fecal-oral transmission route might not apply to all bird IAV host species.