FtsE, the Nucleotide Binding Domain of the ABC Transporter Homolog FtsEX, Regulates Septal PG Synthesis in E. coli

• DOI: 10.1128/spectrum.02863-22
• Publication Date: 2023-04-04T14:33:16Z
• Authors: Sunanda Mallik; Hiren Dodia; Arup Ghosh; Ramanujam Srinivasan; Liam Good; Sunil Kumar Raghav; Tushar Kant Beuria
• Keywords: Adenosine Triphosphatases; Nucleotides; Escherichia coli Proteins; Cystic Fibrosis Transmembrane Conductance Regulator; Cell Cycle Proteins; PG hydrolysis; Peptidoglycan; FtsZ; Microbiology; QR1-502; 3. Good health; FtsX; Amidohydrolases; PG synthesis; Bacterial Proteins; divisome complex; Escherichia coli; ATP-Binding Cassette Transporters; FtsE; Research Article; Protein Binding

The peptidoglycan (PG) layer is an essential component of the E.coli envelope that is required to maintain cellular shape and integrity. Thus, coordinating PG synthesis and hydrolysis at the mid-cell (septal PG) is crucial during bacterial division.