Transcriptome and Gut Microbiota Profiling Analysis of ANIT-Induced Cholestasis and the Effects of Da-Huang-Xiao-Shi Decoction Intervention

• DOI: 10.1128/spectrum.03242-22
• Publication Date: 2022-11-21T14:00:25Z
• Authors: Wang Wang; Shujun Jiang; Chengcheng Xu; Lili Tang; Yan Liang; Yang Zhao; Guoxue Zhu
• Keywords: Da-Huang-Xiao-Shi decoction; 0303 health sciences; Cholestasis; microbiome; Microbiology; QR1-502; United States; Rats; Gastrointestinal Microbiome; 3. Good health; Bile Acids and Salts; 03 medical and health sciences; 1-Naphthylisothiocyanate; Liver; RNA, Ribosomal, 16S; Animals; cholestasis; Pearson correlation analysis; Transcriptome; transcriptome; Research Article

Cholestasis is a serious manifestation of liver diseases resulting in liver injury, fibrosis, and liver failure with limited therapies. To date, only ursodeoxycholic acid (UDCA) has been approved by the U.S.