Virulence Factors of the Gut Microbiome Are Associated with BMI and Metabolic Blood Parameters in Children with Obesity

• DOI: 10.1128/spectrum.03382-22
• Publication Date: 2023-02-14T14:32:28Z
• Authors: S. M. Murga-Garrido; E. J. Ulloa-Pérez; C. E. Díaz-Benítez; Y. C. Orbe-Orihuela; F. Cornejo-Granados; A. Ochoa-Leyva; A. Sanchez-Flores; M. Cruz; A. C. Castañeda-M...; T. Plett-Torres; A. I. Burguete Ga...; A. Lagunas-Martínez
• Keywords: Faecalibacterium prausnitzii; Metabolic pathway; Eubacterium

The development of metabolic diseases is linked to the gut microbiota. A cross-sectional study involving 45 children (6 12 years old) was conducted investigate relationship between microbiota and childhood obesity. Anthropometric measurements, food-frequency questionnaires (FFQs), feces samples were obtained. Using body mass index (BMI) z-score, we categorized each participant as normal weight (NW), or overweight obese (OWOB). We determined 2 dietary profiles: one with complex carbohydrates proteins (pattern 1), other saturated fat simple 2). microbial taxonomic diversity capacity using shotgun metagenomics. found differences both BMI groups diversity. Taxa contributing this difference, included