Streptococcus pneumoniae serotype 33G: genetic, serological, and structural analysis of a new capsule type

• DOI: 10.1128/spectrum.03579-23
• Publication Date: 2023-12-07T14:03:26Z
• Authors: Sam Manna; Joel P. Werren; Belinda D. Ortika; Barbara Bellich; Casey L. Pell; Elissavet Nikolaou; Ilche Gjuroski; Stephanie Lo; Jason Hinds; Odgerel Tundev; Eileen M. Dunne; Bradford D. Gessner; Stephen D. Bentley; Fiona M. Russell; E. Kim Mulholland; Tuya Mungun; Claire von Mollen...; Paul V. Licciardi; Paola Cescutti; Neil Ravenscroft; Markus Hilty; Catherine Satzke
• Keywords: Bacterial capsule; Multilocus sequence typing; Pneumococcal infections; Pneumolysin

(the pneumococcus) is a bacterial pathogen with the greatest burden of disease in Asia and Africa. The pneumococcal capsular polysaccharide has biological relevance as major virulence factor well public health importance it target for currently licensed vaccines. These vaccines have limited valency, covering up to 23 >100 known types (serotypes) higher valency development. Here, we characterized new serotype, which named 33G. We detected serotype 33G nasopharyngeal swabs (