Clonal Complex 12 Serotype Ib Streptococcus agalactiae Strain Causing Complicated Sepsis in Neonates: Clinical Features and Genetic Characteristics

• DOI: 10.1128/spectrum.03778-22
• Publication Date: 2022-12-08T14:02:07Z
• Authors: Jen-Fu Hsu; Yu-Ning Chen; Shih-Ming Chu; Wei-Ju Lee; Hsuan-Rong Huang; Ming-Chou Chiang; Peng-Hong Yang; Ming-Horng Tsai; Jang-Jih Lu
• Keywords: 0301 basic medicine; group B Streptococcus; Infant, Newborn; Infant; multilocus sequence typing; Microbial Sensitivity Tests; Serogroup; Microbiology; QR1-502; severe sepsis; Anti-Bacterial Agents; Streptococcus agalactiae; 3. Good health; serotype Ib CC12 GBS; 03 medical and health sciences; Sepsis; Drug Resistance, Bacterial; Humans; antimicrobial resistance; Serotyping; Research Article

A type Ib ST12 GBS strain is not a common isolate in neonatal invasive diseases and has been ignored for a long time. However, the recent literature and our data showed that such a GBS strain is associated with a significantly higher risk of severe sepsis, higher illness severity, and a significantly higher rate of sepsis-attributable mortality.