Infection Characteristics and Transcriptomics of African Swine Fever Virus in Bama Minipigs

• DOI: 10.1128/spectrum.03834-22
• Publication Date: 2022-11-29T14:05:42Z
• Authors: Changjie Lv; Jingyu Yang; Li Zhao; Chao Wu; Chao Kang; Qiang Zhang; Xiaomei Sun; Xi Chen; Zhong Zou; Meilin Jin
• Keywords: Bama minipig; 0301 basic medicine; virus isolation; Swine; Microbiology; African Swine Fever Virus; Antiviral Agents; QR1-502; 3. Good health; 03 medical and health sciences; African swine fever virus; host-virus infection; Animals; Swine, Miniature; Transcriptome; African Swine Fever; Research Article

African swine fever virus (ASFV) can only infect pigs rather than other animals. However, the domestic pigs cannot be kept in small ABSL-3 laboratories for a long time due to the characteristics of rapid growth and large size, which hinder ASFV research, including research of vaccines, antiviral drugs, and mechanisms.