In Vitro and In Vivo Characterization of H5N8 High-Pathogenicity Avian Influenza Virus Neurotropism in Ducks and Chickens

• DOI: 10.1128/spectrum.04229-22
• Publication Date: 2023-01-10T14:16:20Z
• Authors: Charlotte Foret-L...; Thomas Figueroa; Amelia Coggon; Alexandre Houffsc...; Gabriel Dupré; Maxime Fusade-Boyer; Jean-Luc Guérin; Maxence Delverdier; Pierre Bessière; Romain Volmer
• Keywords: Viral Shedding

H5N8 high-pathogenicity avian influenza virus (HPAIV) of clade 2.3.4.4B, which circulated during the 2016 epizootics in Europe, was notable for causing different clinical signs ducks and chickens. The preceding death were predominantly neurological versus respiratory To investigate determinants predominant observed ducks, we infected duck chicken primary cortical neurons. Viral replication identical neuronal cultures from both species. In addition, did not detect any major difference immune inflammatory responses. These results suggest that involvement HPAIV infection could be recapitulated cultures.