Valproate and risk of fracture in Rett syndrome

• DOI: 10.1136/adc.2008.148932
• Publication Date: 2010-05-25T09:48:30Z
• Authors: H. Leonard; J. Downs; L. Jian; A. Bebbington; P. Jacoby; L. Nagarajan; D. Ravine; H. Woodhead
• Keywords: Rett Syndrome

<h3>Objectives</h3> Some associations between antiepileptic drugs (AEDs) and fracture risk have been reported in the general population. This study investigated relationships commonly used AEDs Rett syndrome, a genetic disorder associated with intellectual physical disability. <h3>Study design</h3> Cases (n=233) were sourced from population-based Australian Syndrome Database longitudinal data used. The Cox proportional hazard model was to analyse prescribed AEDs, mobility, epilepsy diagnosis genotype. <h3>Results</h3> After controlling for genotype, use of valproate increased threefold after at least 1 year (HR 3.56; 95% CI 1.85 6.82) 2 or more years 3.02; 1.90 4.80). There lesser 1.99; 0.99 4.02) lamotrigine first but not subsequent use. Carbamazepine slightly decreased 0.60; 0.35 1.02) <h3>Conclusions</h3> effect on bone health should be considered when managing syndrome. Multiple mechanisms could contributing this effect.