Radiolabelled leucocytes: a new diagnostic tool in occult infection/inflammation.

• DOI: 10.1136/adc.59.1.62
• Publication Date: 2008-12-22T21:51:33Z
• Authors: I Gordon; G Vivian
• Keywords: Occult; White blood cell

Autologous white blood cells were labelled with Indium 111 (111In wbc) and reinjected into 18 children suspected infection 10 inflammatory bowel disease aged 5 weeks to 15 years. In addition two immunosuppressed received donor 111In wbc. Gamma camera images obtained between one four hours 20 24 hours. Other appropriate investigations also undertaken in these children. Of positive wbc scans 17 true positive. There 12 negative of which 9 three false negative. The overall results showed a sensitivity 85%, specificity 90%, an accuracy 86%. Used appropriately this technique forms valuable back up investigation.