Haemolytic uraemic syndromes in the British Isles 1985-8: association with verocytotoxin producing Escherichia coli. Part 1: Clinical and epidemiological aspects.

• DOI: 10.1136/adc.65.7.716
• Publication Date: 2008-12-22T22:39:16Z
• Authors: D V Milford; C M Taylor; B Guttridge; S M Hall; B Rowe; H Kleanthous
• Keywords: Verocytotoxin; Haemolytic-uraemic syndrome; Prodrome

A prospective study of the clinical and epidemiological features haemolytic uraemic syndromes was conducted over a three year period in British Isles. Two hundred ninety eight children were reported. In two thirds cases stool samples analysed for presence Verocytotoxin producing Escherichia coli (VTEC) neutralisable Verocytotoxin. total 273 (95%) patients had prodrome diarrhoea. these seasonal variation incidence syndrome demonstrated, 1-2 age range most often affected, peripheral blood neutrophil count correlated positively with an adverse outcome. Patients presenting without diarrhoea showed none associations significantly greater morbidity mortality. Evidence VTEC infection found 58 (33%) 178 associated whose stools analysed, although identified five (62%) collected within days onset Most isolates produced VT2 either alone, or together VT1. There no evidence prodromal