Bone resorption by cells isolated from rheumatoid synovium.

• DOI: 10.1136/ard.51.11.1223
• Publication Date: 2008-07-28T23:49:46Z
• Authors: J.S Chang; J.M Quinn; A Demaziere; C.J Bulstrode; M.J Francis; R.B Duthie; N.A Athanasou
• Keywords: Osteolysis

Cellular mechanisms accounting for the osteolysis of rheumatoid erosions are poorly understood. Cells were isolated and characterised from synovium 16 patients with arthritis (RA) four osteoarthritis their ability to resorb bone was assessed using a scanning electron microscope resorption assay. Macrophages major cell type RA. These produced extensive roughening surface without pit formation. This low grade not affected by systemic (calcitonin, parathyroid hormone, 1,25-dihydroxyvitamin D3) or local (interleukin 1, prostaglandin E2) factors influencing resorption. Macrophage mediated differs qualitatively quantitatively that osteoclasts but is likely play an important part in development marginal