2136 The association of ABO and Rh blood groups with 30-day mortality following traumatic injury – a retrospective observational study

• DOI: 10.1136/emj-2023-rcem.40
• Publication Date: 2024-02-07T07:28:33Z
• Authors: Jane Li; Rachel Bell; Ed Barnard; Liam Barrett; Bushry Basheer; Jacques Bowman; Adrian Boyle
• Keywords: Interquartile range; Major trauma

<h3>Aims and Objectives</h3> Trauma is a leading cause of death for those under 44. Patients with blood group O (bgO) have been reported to higher mortality. The existing hypothesis (that lower levels circulating von Willebrand factor/factor VIII in patients bgO increases mortality through bleeding tendency) has not tested. Our study uniquely investigates the association between all ABO Rh groups 30-day all-cause large adult trauma patient cohort. Understanding post-trauma physiological shifts may identify potential therapeutic targets attenuate risks. <h3>Method Design</h3> All ≥16 years old attending East England Major Centre (2016-2019) who met Audit Research Network (TARN) criteria were included. primary outcome was mortality; secondary outcomes included admission clotting profile (PT/aPTT). Data as number (percentage), median [interquartile range]. Proportions compared Chi-square test, relative risk (95% confidence interval) (RR (95%CI)). Continuous data Kruskal-Wallis p-value. analyses performed Python v.3.8.9. Bonferroni correction used multiple comparisons. <h3>Results Conclusion</h3> 4188 age 59.3 [39.0-77.9] years, n=2634 (62.9%) male, injury severity score 19 [10-25], 9.3%. Pairwise comparison demonstrated increased negative (Oneg) three other groups, table 1. Compared combined, Oneg had significantly greater – 15.1% 8.8%; RR 1.72 (95%CI 1.32-2.24), p=0.0002 (significance defined p&lt;0.0063 (eight comparisons)). There no difference PT or aPTT p=0.12 p=0.26 respectively. which questions underlying mechanism.