Dickkopf 1 impairs the tumor response to PD-1 blockade by inactivating CD8+ T cells in deficient mismatch repair colorectal cancer

• DOI: 10.1136/jitc-2020-001498
• Publication Date: 2021-03-29T15:10:46Z
• Authors: Qiaoqi Sui; Dingxin Liu; Wu Jiang; Jinghua Tang; Lingheng Kong; Kai Han; Leen Liao; Yuan Li; Qingjian Ou; Binyi Xiao; Guochen Liu; Yihong Ling; Jiewei Chen; Zexian Liu; Zhixiang Zuo; Zhizhong Pan; Penghui Zhou; Jian Zheng; Pei-Rong Ding
• Keywords: Adult; Male; Programmed Cell Death 1 Receptor; CD8-Positive T-Lymphocytes; DNA Mismatch Repair; Jurkat Cells; 03 medical and health sciences; Lymphocytes, Tumor-Infiltrating; 0302 clinical medicine; Immunotherapy Biomarkers; Animals; Humans; Immune Checkpoint Inhibitors; RC254-282; Aged; Aged, 80 and over; Mice, Inbred BALB C; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Middle Aged; Coculture Techniques; 3. Good health; Treatment Outcome; Intercellular Signaling Peptides and Proteins; Female; Colorectal Neoplasms; Signal Transduction

Dickkopf 1 (DKK1) is associated with tumor progression. However, whether DKK1 influences the response to programmed cell death protein (PD-1) blockade in colorectal cancers (CRCs) deficient mismatch repair (dMMR) or microsatellite instability (MSI) has never been clarified.