PO.8.184 Will there be a pattern of nailfold video-capillaroscopy in patients with systemic lupus erythematosus?

• DOI: 10.1136/lupus-2022-elm2022.202
• Publication Date: 2022-09-27T10:26:16Z
• Authors: C Mazeda; S Silva; S Azevedo; A Barcelos
• Keywords: Outpatient clinic

<h3>Purpose</h3> Systemic Lupus Erythematosus (SLE) is a chronic and multisystem autoimmune disorder characterized by heterogeneity of clinical presentations. Clinical expression the consequence production autoantibodies immune complex vasculitis with endothelial cell damage leading to blood vessel destruction serious internal organ dysfunction. Nailfold video-capillaroscopy (NVC) non-invasive inexpensive tool that allows assess microvascular involvement. In SLE only normal patterns variety 'non-specific' capillary abnormalities have been observed. The aim this study was evaluate capillaroscopic changes patients correlation involvement, laboratory findings disease activity. <h3>Methods</h3> A retrospective performed including followed in outpatient rheumatology clinic; healthy controls primary Raynaud's phenomenon (RP) were also enrolled study. Socio-demographic data collected. Descriptive analysis performed; p-value≤0.05 statistically significant. <h3>Results</h3> 50 (47 female; 3 men) (42 8 are included, averaging 47.1±13.6 50.3±18.8 years old, respectively (p=0.33). Mean duration 10.6±7.7 most frequent involvements hematological (64%), cutaneous (64%) musculoskeletal (56%). Only 18% had RP. All positive ANAs (36% anti-dsDNA, 32% anti-Ro60, 26% anti-Ro52, 10% anti-SSB, 4% anti-RNP anti-Smith) 20% antiphospholipid antibodies. 76% remission rest minimal activity according SLEDAI-2K. capillaroscopy findings, showed pattern morphological alterations tortuous capillaries (30%) presence hemorrhages (10%). (5%) (2%). patients, we found significant differences regarding morphology NVC nervous system involvement (p=0.04 p=0.01, respectively) as well SLEDAI score (p=0.04). When comparing controls, morphology, phenomenon, antinuclear antibodies two groups (p&lt;0.05). <h3>Conclusions</h3> As previous studies, our nonspecific (abnormal haemorrhages) patients. Some seem be associated activity, but studies larger sample sizes warranted may beneficial its evolution over time understand impact on outcome.