Follow-up neutrophil-lymphocyte ratio after stroke thrombectomy is an independent biomarker of clinical outcome

• DOI: 10.1136/neurintsurg-2020-016342
• Publication Date: 2020-08-06T21:16:39Z
• Authors: Moustafa Aly; Ramez N Abdalla; Ayush Batra; Ali Shaibani; Michael C Hurley; Babak S Jahromi; Matthew B Potts; Sameer A Ansari
• Keywords: Stroke; Univariate analysis

Background Admission neutrophil-lymphocyte ratio (NLR) is significantly correlated to clinical outcomes in acute ischemic stroke (AIS). We investigated follow-up NLR and temporal changes after endovascular thrombectomy (EVT) with respect successful revascularization, outcomes, symptomatic intracranial hemorrhage (sICH) mortality. Methods Retrospective analysis of EVT for anterior circulation emergent LVO was performed both admission (NLR1) 3–7 day (NLR2) laboratory data. Patient demographics, National Institutes Health Stroke Scale (NIHSS) presentations, reperfusion efficacy (modified Thrombolysis Cerebral Infarction (mTICI) score), sICH, Rankin (mRS)) at 90 days were studied. Univariate analyses NLR1, NLR2, change (NLR2-NLR1) (mTICI ≥2b), favorable (mRS ≤2), Multivariable logistic regression model evaluated the independent effects NLR2 on outcomes. Results 142 AIS patients median NIHSS 17 underwent within 24 hours, met inclusion criteria. Lower less over days, but not inversely (p<0.05) (p<0.001). Higher greater associated sICH mortality (p≤0.05). In multivariable regression, lower remained a predictor (OR 0.785, p=0.001), age or reperfusion. Conclusions Follow-up readily available modifiable biomarker that correlates degree mechanical thrombectomy. an reduced risk