Aberrant Prefrontal–Thalamic–Cerebellar Circuit in Schizophrenia and Depression: Evidence From a Possible Causal Connectivity

• DOI: 10.1142/s0129065718500326
• Publication Date: 2018-07-16T05:12:01Z
• Authors: Yuchao Jiang; Mingjun Duan; Xi Chen; Xingxing Zhang; Jinnan Gong; Debo Dong; Hui Li; Qizhong Yi; Shuya Wang; Jijun Wang; Cheng Luo; Dezhong Yao
• Keywords: Middle frontal gyrus

Neuroimaging studies have suggested the presence of abnormalities in prefrontal–thalamic–cerebellar circuit schizophrenia (SCH) and depression (DEP). However, common distinct structural causal connectivity this between two disorders are still unclear. In current study, resting-state functional magnetic resonance imaging (fMRI) data were acquired from 20 patients with SCH, depressive healthy controls (HC). Voxel-based morphometry analysis was first used to assess gray matter volume (GMV). Granger causality analysis, seeded at regions altered GMVs, subsequently conducted. To discover differences groups, ANCOVA post hoc tests performed. Then, relationships changes, clinical variables investigated. Finally, a leave-one-out resampling method implemented test consistency. Statistical analyses showed GMV changes circuit. Compared HC, both SCH DEP exhibited decreased middle frontal gyrus (MFG), lower MFG medial prefrontal cortex (MPFC) than DEP. patient groups increased flow right cerebellum MPFC (common abnormalities). And (increased left thalamus HC DEP, SCH). addition, deficits its associated negative symptom severity SCH. This study found common/distinct aberrant patterns which may provide potential direction for understanding convergent divergent psychiatric pathological mechanisms Furthermore, concomitant jointly contribute symptoms