Angiosarcoma of the Spleen: Imaging Characteristics in 12 Patients

• DOI: 10.1148/radiol.2351040308
• Publication Date: 2007-04-10T17:05:44Z
• Authors: William M. Thompson; Angela D. Levy; Nadine S. Aguilera; Luis Gorospe; Robert M. Abbott
• Keywords: Echogenicity; Hemangiosarcoma; Splenic disease

PURPOSE: To retrospectively review clinical, pathologic, and imaging features of angiosarcoma the spleen in 12 patients. MATERIALS AND METHODS: Institutional board approval was obtained, informed consent not required. Records cases proved were accessed from files Armed Forces Institute Pathology. Clinical, findings reviewed. Presenting signs symptoms recorded, pathologist confirmed diagnosis determined gross microscopic morphologic each spleen. Radiologists reviewed available images to determine size mass, amount splenic involvement by tumor (if enhanced at computed tomography [CT] magnetic resonance [MR] imaging), nonviable as decreased echogenicity ultrasonography (US) lack enhancement CT MR imaging. Imaging pathologic compared. Five US, 10 CT, three MR, two angiographic experienced abdominal radiologists. RESULTS: There seven men five women (age range, 36–86 years; mean, 55 years). The most common symptom upper pain eight (67%) patients: Pain acute for 24 hours prior admission one patient chronic (range, 1–6 months) At imaging, enlarged (>12 cm length) nine finding, seen (58%) patients, a complex mass or masses an Four these patients had evidence metastases intraperitoneal hemorrhage. Two solitary hypervascular tumors liver metastases. One normal-sized with multiple lesions that ranged 2–3 size, well spine. 11th small lesions, calcifications periphery lesion. 12th intraabdominal hemorrhage around no obvious CT. Tumor necrosis histologic evaluation CONCLUSION: clinical finding pain. Angiosarcoma could be suggested majority (83%) using metastatic disease. © RSNA, 2005