“Fill States”: PET-derived Markers of the Spatial Extent of Alzheimer Disease Pathology

• DOI: 10.1148/radiol.241482
• Publication Date: 2025-03-25T13:53:36Z
• Authors: Elena Doering; Merle C. Hoenig; Kathrin Giehl; Verena Dzialas; Grégory Andrassy; Abdelmajid Bader; Andreas Bauer; David Elmenhorst; Johannes Ermert; Silke Frensch; Elena Jäger; Frank Jessen; Philipp Krapf; Tina Kroll; Christoph Lerche; Julia Lothmann; Andreas Matusch; Bernd Neumaier; Oezguer A. Onur; Alfredo Ramirez; Nils Richter; Frederik Sand; Lutz Tellmann; Hendrik Theis; Philip Zeyen; Thilo van Eimeren; Alexander Drzezga; Gérard N. Bischof

The spatial extent of amyloid, tau, and neurodegeneration, derived from PET imaging, has higher diagnostic performance for cognitive impairment severity compared with standardized uptake value ratios.