Metabolic Imaging of Myocardial Triglyceride Content: Reproducibility of1H MR Spectroscopy with Respiratory Navigator Gating in Volunteers

• DOI: 10.1148/radiol.2451061904
• Publication Date: 2008-01-05T00:54:37Z
• Authors: Rutger W. van der...; Joost Doornbos; Sebastian Kozerke; Michael Schär; Jeroen J. Bax; Sebastiaan Hammer...; Johannes W. A. Smit; Johannes A. Romijn; Michaela Diamant; Luuk J. Rijzewijk; Albert de Roos; Hildo J. Lamb
• Keywords: Adult; Male; Magnetic Resonance Spectroscopy; Myocardium; Respiration; Reproducibility of Results; 610 Medicine & health; Middle Aged; 3. Good health; 170 Ethics; Motion; 03 medical and health sciences; 0302 clinical medicine; 2741 Radiology, Nuclear Medicine and Imaging; Humans; 10237 Institute of Biomedical Engineering; Female; Prospective Studies; Triglycerides

Institutional review board approval and informed consent were obtained. The purpose of the study was to prospectively compare spectral resolution reproducibility hydrogen 1 (1H) magnetic resonance (MR) spectroscopy, with without respiratory motion compensation based on navigator echoes, in assessment myocardial triglyceride content human heart. In 20 volunteers (14 men, six women; mean age ± standard error, 31 years 2.8 [range, 19–60 years]; body mass index, 19–30 kg/m2) history cardiovascular disease, 1H MR spectroscopy myocardium performed at rest, compensation. Unsuppressed water signal linewidth changed from 11.9 Hz 10.7 (P < .001) use navigator, which indicated better resolution. improved intraclass correlation coefficient for 0.32 0.81. Therefore, authors believe that correction is essential reproducible triglycerides. © RSNA, 2007