Green Electrochemical Sensing: Novel Ion-Selective Electrode Method for Precise Determination of Dimenhydrinate and its Metabolite along with Cinnarizine in Pharmaceutical and Plasma Samples

• DOI: 10.1149/1945-7111/ad4ba4
• Publication Date: 2024-05-14T23:02:17Z
• Authors: Shereen A. Boltia; Eman M. Morgan; Reem H. Obaydo; Yasmin M. Fayez; M. Abdelkawy; Hayam M. Lotfy
• Keywords: Cinnarizine; ITIES

Green and sustainable scientific research is crucial for health environmental improvement. Electrochemical analysis simplifies complex processes, saving time cost. Ion selective electrode method, a key in green analytical chemistry, was utilized. A highly solid contact sensor developed two applications, detecting cinnarizine (CIN) dimenhydrinate (DMH) pharmaceuticals, identifying CIN diphenhydramine (DIP) human plasma. Careful selection of ionophores ensured accurate detection. Multi-wall carbon-nanotubes (MWCNTs) facilitate rapid precise measurement. The concentration range CIN, DMH, DIP 1 × 10 −6 M to −2 M, with mean recovery% 100.07 ± 0.80, 100.12 0.76, 0.53, respectively. Validation parameters exhibited accuracy precision, results 100.87 0.89, 99.96 0.42, 99.82 0.31, LODs 0.5 , 1.0 −7 0.2 DIP, study highlighted benefits like speed, economy, sustainability, emphasizing the electrode’s reusability. SWOT assessments further underscored its advantages, promising applications pharmaceutical quality control.