Perfluorooctane sulfonate-induced Sertoli cell injury through c-Jun N-terminal kinase: a study by RNA-Seq

• DOI: 10.1152/ajpcell.00212.2024
• Publication Date: 2024-06-03T08:02:14Z
• Authors: Sheng Gao; Zifeng Chen; Xiaolong Wu; Lingling Wang; Tiao Bu; Linxi Li; Xinyao Li; Damin Yun; Fei Sun; C. Yan Cheng
• Keywords: 0301 basic medicine; 03 medical and health sciences

PFOS induces Sertoli cell injury, including disruption of the 1) blood-testis barrier function and 2) cytoskeletal organization, which, in turn, impedes male reproductive function. These changes are mediated by JNK/p-JNK signaling pathway. However, the use of KB-R7943, a JNK/p-JNK activator was capable of blocking PFOS-induced Sertoli cell injury, supporting the possibility of therapeutically managing PFOS-induced reproductive dysfunction.