Human skeletal muscle possesses an epigenetic memory of high-intensity interval training

• DOI: 10.1152/ajpcell.00423.2024
• Publication Date: 2024-11-21T16:29:59Z
• Authors: Andrea M. Pilotto; Daniel C. Turner; Raffaele Mazzolari; Emanuela Crea; Lorenza Brocca; Maria Antonietta ...; Danilo Miotti; Roberto Bottinelli; Adam P. Sharples; Simone Porcelli
• Keywords: DNA methylation; 610; endurance exercise; muscle memory; gene transcription

Cells possess a “memory” such that adaptations can be more quickly regained when a previously encountered challenge is reintroduced. Exercise provides an excellent experimental model to explore the concept of cellular memory to physiologically relevant stressors in humans. This study highlights molecular mechanisms that contribute to muscle memory in response to high-intensity interval training in humans, showing retention of DNA methylation and gene expression profiles from earlier training into detraining and retraining.