β-Adrenergic signaling drives structural and functional maturation of mouse cardiomyocytes

• DOI: 10.1152/ajpcell.00426.2023
• Publication Date: 2024-04-01T08:10:36Z
• Authors: Marcos Eliezeck; Itamar Couto Gued...; Sérgio A. Scalzo; Bruno de Lima San...; Kaoma Stephani Co...; Mateus Costa; Thássio Mesquita; Cibele Rocha-Resende; Raphael E. Szawka; Silvia Guatimosim
• Keywords: Male; 0301 basic medicine; Adrenergic beta-Antagonists; Isoproterenol; Heart; Adrenergic beta-Agonists; Propranolol; Mice, Inbred C57BL; Mice; Norepinephrine; 03 medical and health sciences; Receptors, Adrenergic, beta; Animals; Myocytes, Cardiac; Cells, Cultured; Signal Transduction

Maturation involves a series of morphofunctional alterations vital to heart development. Its regulatory mechanisms are only now being unveiled. Evidence implies that adrenergic signaling regulates cardiac maturation, but the mechanisms are poorly understood. To address this point, we blocked β-ARs or performed sympathectomy followed by rescue experiments with isoproterenol in neonatal mice. Our study identifies the β-AR stimuli as a maturation signal for cardiomyocytes and highlights the importance of this pathway in cardiac regeneration therapies.