Sel1-like proteins and peptides are the major Oxalobacter formigenes-derived factors stimulating oxalate transport by human intestinal epithelial cells

• DOI: 10.1152/ajpcell.00466.2021
• Publication Date: 2023-05-01T12:36:26Z
• Authors: Donna Arvans; Changsoo Chang; Altayeb Alshaikh; Christine Tesar; Gyorgy Babnigg; Don Wolfgeher; Stephen Kron; Dionysios Antonop...; Mohamed Bashir; Candace Cham; Mark Musch; Eugene Chang; Andrzej Joachimiak; Hatim Hassan
• Keywords: Oxalates; Hyperoxaluria; Oxalobacter formigenes; Epithelial Cells; Kidney Transplantation; Mice; Kidney Calculi; 03 medical and health sciences; 0302 clinical medicine; Humans; Animals; Renal Insufficiency; Caco-2 Cells; Renal Insufficiency, Chronic; Peptides

We previously identified Oxalobacter formigenes-derived secreted factors stimulating oxalate transport by human intestinal epithelial cells in vitro and reducing urinary oxalate excretion in hyperoxaluric mice by enhancing colonic oxalate secretion. We now identified Sel1-like proteins and small peptides as the major secreted factors and they have significant therapeutic potential for hyperoxalemia and hyperoxaluria, impacting the outcomes of patients suffering from kidney stones, primary and secondary hyperoxaluria, chronic kidney disease, kidney failure, and renal transplant recipients.