Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle

• DOI: 10.1152/ajpcell.1994.267.6.c1723
• Publication Date: 2017-12-24T18:48:50Z
• Authors: V. Smerdu; I. Karsch-Mizrachi; M. Campione; L. Leinwand; S. Schiaffino
• Keywords: Homology

Several members of the sarcomeric myosin heavy chain (MHC) gene family have been mapped in human genome but many them not yet identified. In this study we report identification two skeletal MHC genes as fast IIa and IIx based on pattern expression sequence homology with corresponding rat 3'-translated untranslated regions. The distribution these products well that beta/slow was analyzed muscles by situ hybridization. beta/slow, IIa, transcripts defines three major muscle fiber types expressing a single mRNA, i.e., either or populations hybrid fibers coexpressing mRNA. Fiber typing ATPase histochemistry shows are more abundant histochemical type fibers, whereas IIb fibers.