Effects of exogenous lactate on lipid, protein, and glucose metabolism—a randomized crossover trial in healthy males

• DOI: 10.1152/ajpendo.00301.2023
• Publication Date: 2024-02-07T16:16:11Z
• Authors: Mette G. B. Pedersen; Nikolaj Rittig; Maj Bangshaab; Kristoffer Berg-H...; Nigopan Gopalasingam; Lars C. Gormsen; Esben Søndergaard; Niels Møller
• Keywords: Crossover study; Carbohydrate Metabolism

Lactate is a decisive intermediary metabolite, serving as an energy substrate and signaling molecule. The present study examines the effects of lactate on metabolism insulin sensitivity in healthy males. Hyperlactatemia reduces lipolysis by 30% without affecting glucose metabolism. In addition, hyperlactatemia increases whole body amino acid turnover rate.