Experimental chronic hypoxic neuropathy: relevance to diabetic neuropathy

• DOI: 10.1152/ajpendo.1986.250.1.e94
• Publication Date: 2017-12-21T16:35:29Z
• Authors: P. A. Low; J. D. Schmelzer; K. K. Ward; J. K. Yao
• Keywords: Hypoxia; Diabetic Neuropathy; Electroneuronography; Hexokinase

The cardinal electrophysiological abnormalities in experimental diabetic (EDN) and galactose (EGN) neuropathy, models which endoneurial hypoxia has been demonstrated, are a slowing nerve conduction velocity (NCV) resistance to ischemic block (RICB). These also present human where microangiopathy demonstrated be more severe than EDN so that is likely present. We examined the effects of per se on normal nerves. In rats subjected chronic (10% O2) for up 10 wk, two had developed by 4 wk were very similar degree those seen EGN. occurred absence hyperglycemia, sorbitol accumulation, or myoinositol reduction. Resting O2 consumption was reduced, percent increase lactate under anoxic stress increased, free sugars normal. Hexokinase phosphofructokinase activities not altered substantially when studied conditions excess. findings indicate will cause suggest hypoxic develops RICB because reduced energy requirement an increased efficiency anaerobic glycolysis, but without major changes activity its controlling glycolytic enzymes.