Preoperative oral carbohydrate treatment attenuates immediate postoperative insulin resistance

• DOI: 10.1152/ajpendo.2001.280.4.e576
• Publication Date: 2017-12-22T18:10:11Z
• Authors: Mattias Soop; Jonas Nygren; Peter Myrenfors; Anders Thorell; Olle Ljungqvist
• Keywords: Carbohydrate Metabolism

Postoperative insulin resistance is a well-characterized metabolic state that has been shown to correlate with the length of postoperative stay in hospital. Preoperative intravenous or oral carbohydrate treatment attenuate development measured 1 day after surgery. To study effects preoperative on changes and substrate utilization, absence confounding factors, 15 patients were double-blindly treated either carbohydrate-rich beverage (12.5%) ( n = 8) placebo 7) before undergoing total hip replacement Insulin sensitivity, endogenous glucose release, oxidation rates immediately Whole body sensitivity decreased by 18% group vs. 43% P < 0.05, Student's t-test for unpaired data). In both groups, major mechanism was an inhibition insulin-induced nonoxidative disposal The better preservation attributable less reduced peripheral tissues increased rates.