Decaying kidney function during cirrhosis correlates with remodeling of distal colon aldosterone target gene expression

• DOI: 10.1152/ajpgi.00073.2023
• Publication Date: 2023-07-18T08:02:49Z
• Authors: Natalia Serrano-M...; Carlos González-A...; Arianna Vastola-M...; Ana E. Rodríguez-...; Guadalberto Herná...; Esteban Porrini; Manuel Hernández-...; Diego Alvarez de ...
• Keywords: Mineralocorticoid

Liver cirrhosis is associated to circulatory abnormalities leading hypovolemia and stimulation of the renin-angiotensin-aldosterone system (RAAS). Advanced stages disease cause renal failure, impairing K+ Na+ homeostasis. It has been proposed that distal colon undergoes functional remodeling during in particular by aldosterone-driven increased excretion. In this study, we compared transcriptional response aldosterone target genes rat under two models circulating (one with concomitant RAAS activation) a model secondary hyperaldosteronism induced cirrhosis. The expression subset these was also tested biopsies from control subjects or patients varying levels progression treated not mineralocorticoid receptor inhibitor spironolactone. We examined known aldosterone-regulated transcripts involved corticosteroid signaling transepithelial ion transport. addition, included related cell proliferation. Our comparison revealed multiple upregulated decompensated Epithelial channel β γ subunit correlated positively plasma concentration negatively glomerular filtration rate. Patients showed 11-β-hydroxysteroid-dehydrogenase 2 (11βHSD2), which reverted spironolactone treatment, suggesting sensitization action. summary, our data show decaying kidney function toward state correlates transporter expression, supporting role for process.NEW & NOTEWORTHY significantly alters colon, change well declining severity disease. suggest steroid hormone participates homeostatic maintain electrolyte balance.