Neuroimmune interactions in guinea pig stomach and small intestine

• DOI: 10.1152/ajpgi.00241.2002
• Publication Date: 2015-03-03T23:31:46Z
• Authors: Sumei Liu; Hong-Zhen Hu; Na Gao; Chuanyun Gao; Guodu Wang; Xiyu Wang; Owen C. Peck; Gordon Kim; Xiang Gao; Yun Xia; Jackie D. Wood
• Keywords: Enteric Nervous System; Thioperamide; Ketotifen

Enteric neuroimmune interactions in gastrointestinal hypersensitivity responses involve antigen detection by mast cells, cell degranulation, release of chemical mediators, and modulatory actions the mediators on enteric nervous system (ENS). Electrophysiological methods were used to investigate electrical synaptic behavior neurons stomach small intestine during exposure β-lactoglobulin guinea pigs sensitized cow's milk. Application preparations depolarized membrane potential increased neuronal excitability intestinal but not gastric neurons. Effects suppressed stabilizing drug ketotifen, histamine H 2 receptor antagonist cimetidine, cyclooxygenase inhibitor piroxicam, 5-lipoxygenase caffeic acid. Unlike ganglion myenteric did respond applied exogenously. Antigenic noradrenergic inhibitory neurotransmission submucosal plexus. The 3 thioperamide acid, prevented allergic suppression neurotransmission. stimulation transmission occurred only milk-sensitized animals. Results suggest that signaling between cells ENS underlies intestinal, gastric, anaphylactic associated with food allergies. Histamine, prostaglandins, leukotrienes are paracrine signals communication pathway from ENS.