The administration of amnion-derived multipotent cell secretome ST266 protects against necrotizing enterocolitis in mice and piglets

• DOI: 10.1152/ajpgi.00364.2021
• Publication Date: 2022-07-12T12:02:11Z
• Authors: Chhinder P. Sodhi; Raheel Ahmad; Hongpeng Jia; William B. Fulton; Carla Lopez; Andres J. Gonzale...; Asuka Ishiyama; Maame Sampah; Steve Steinway; Sanxia Wang; Thomas Prindle; Menghan Wang; David L. Steed; Howard Wessel; Ziv Kirshner; Larry R. Brown; Peng Lu; David J. Hackam
• Keywords: 0303 health sciences; Swine; Multipotent Stem Cells; 3. Good health; Toll-Like Receptor 4; Disease Models, Animal; Mice; 03 medical and health sciences; Enterocolitis, Necrotizing; Animals; Amnion; Intestinal Mucosa; Secretome

This work provides hope for children who develop NEC, a devastating disease of premature infants that is often fatal, by revealing that the secreted product of amniotic progenitor cells (called ST266) can prevent or treat NEC in mice, piglet, and “NEC-in-a-dish” models of this disease. Mechanistically, ST266 prevented bacterial signaling, and a detailed transcriptomic analysis revealed effects on gut differentiation, immunity, and metabolism. Thus, an amniotic secretome may offer novel approaches for NEC.