Influence of microbial species on small intestinal myoelectric activity and transit in germ-free rats

• DOI: 10.1152/ajpgi.2001.280.3.g368
• Publication Date: 2017-12-24T15:45:34Z
• Authors: Einar Husebye; Per M. Hellström; Frank Sundler; Jie Chen; Tore Midtvedt
• Keywords: Bifidobacterium bifidum

The effect of an intestinal microflora consisting selected microbial species on myoelectric activity small intestine was studied using germ-free rat models, with recording before and after specific colonization, in the unanesthetized state. Intestinal transit, neuropeptides blood (RIA), neuromessengers wall were determined. Clostridium tabificum vp 04 promoted regular spike burst activity, shown by a reduction migrating complex (MMC) period from 30.5 ± 3.9 min state to 21.2 0.14 ( P < 0.01). Lactobacillus acidophilus A10 Bifidobacterium bifidum B11 reduced MMC 27.9 4.5 21.5 2.1 0.02) accelerated transit 0.05). Micrococcus luteus showed inhibitory effect, 35.9 9.3 compared 27.7 6.3 rats Inhibition indicated also for Escherichia coli X7gnotobiotic rats. No consistent changes slow wave frequency observed. concentration neuropeptide Y decreased introduction conventional microflora, suggesting control. bacteria promote or suppress initiation aboral migration depending involved. Bacteria primitive fermenting metabolism (anaerobes) emerge as important promoters intestine.