Mechanisms involved in cardiovascular and hydroelectrolytic changes in dehydrated high-fat-diet-fed rats

• DOI: 10.1152/ajpregu.00171.2024
• Publication Date: 2025-03-10T08:30:56Z
• Authors: Jéssica Matheus Sá; Marcos Vinícius F...; Roberto Braz Pontes; Eduardo Colombari; José Vanderlei Me...; Débora Simões Alm...

Obesity is increasingly prevalent worldwide, and climate change exacerbating water shortages, leading to dehydration. Both obesity dehydration cause increased arterial pressure (AP), fluid electrolytic imbalance, neuroinflammation. Thus, the present study aimed verify changes in cardiovascular system, hydroelectrolytic balance microglia neuronal activation rats fed with a high-fat diet (HFD) response 24 h of deprivation (WD) possible mechanisms involved. Male Holtzman (290-310 g) were standard (SD, 10% calories from fat) or HFD (46% for 6 weeks before WD experiments. Compared SD rats, presented greater c-Fos immunolabelling subfornical organ (SFO) supraoptic nucleus microglial SFO. WD-induced intake was lower than rats. anti-diuresis lesser natriuresis Renal denervation did not observed SD-fed The might be due neuroinflammation and/or decreased urinary output. increase AP after similar between SD, but it more dependent on AT1 receptor Overall, seem less responsive electrolyte responses WD, highlighting need strategies prevent obese individuals, particularly during rising drought conditions worldwide.