Adaptation of the hepatic transudation barrier to sinusoidal hypertension

• DOI: 10.1152/ajpregu.00178.2019
• Publication Date: 2020-02-05T20:48:40Z
• Authors: Ranjeet M. Dongao...; Christopher M. Quick; Glen A. Laine; Karen Uray; Charles S. Cox; Randolph H. Stewart
• Keywords: Male; 0301 basic medicine; 03 medical and health sciences; Dogs; Liver; Hypertension; Animals; Ascites; Constriction, Pathologic; Exudates and Transudates; Adaptation, Physiological

The role of the hepatic transudation barrier in determining ascites volume and protein content chronic liver disease is poorly understood. Therefore, purpose present study was to characterize how sinusoidal hypertension impacts properties rate. suprahepatic inferior vena cava surgically constricted, animals were exposed either short-term (SVH; 2–3 wk) or long-term venous (LVH; 5–6 wk). Compared with SVH, LVH resulted lower peritoneal fluid pressure, volume, concentration. reflection coefficient significantly higher, hydraulic conductivity, rate, transudate-to-lymph concentration ratio compared SVH animals. sensitivity rates acute changes interstitial pressures also In contrast, there no detectable difference lymph flow rate between Taken together, these data suggest that decreased permeability increased led a decrease contribution volume. work, best our knowledge, first quantify an anti-ascites adaptation response hypertension.