Acclimatization to neurological decompression sickness in rabbits

• DOI: 10.1152/ajpregu.00260.2004
• Publication Date: 2004-07-30T00:24:16Z
• Authors: Chien-Ling Su; Chin-Pyng Wu; Shao-Yuan Chen; Bor-Hwang Kang; Kun-Lun Huang; Yu-Chong Lin
• Keywords: 0303 health sciences; 03 medical and health sciences; Hot Temperature; Behavior, Animal; Acclimatization; Diving; Animals; HSP70 Heat-Shock Proteins; Tissue Distribution; Rabbits; Nervous System Diseases; Decompression Sickness

Diving acclimatization refers to a reduced susceptibility acute decompression sickness (DCS) in individuals undergoing repeated compression-decompression cycles. We demonstrated previous study that the mechanism responsible for this is similar of stress preconditioning. In study, we investigated protective effect prior DCS preconditioning on severity neurological subsequent exposure high pressure rabbits. exposed rabbits (n = 10) cycle 6 absolute atmospheres (ATA) 90 min, which induced signs 60% animals. Twenty-four hours after cycle, with expressed more heat-shock protein 70 (HSP70) lungs, liver, and heart than without disease or those control group 6). another 24), 50% animals presented pressure, score 46.5 (SD 19.5). A course hyperbaric oxygen therapy alleviated ensured animals' survival 24 h. Experiencing ATA 12 developed DCS, 16.3 28.3), significantly lower before (P 0.002). summary, our results show occurrence rapid associated increased expression protein, indicating response by DCS. This phenomenon was defined as "DCS preconditioning." attenuated caused pressure. These suggest bubble formation tissues activates attenuates tissue injury stress, may be diving acclimatization.