Combined mental task and metaboreflex impair cerebral oxygenation in patients with type 2 diabetes mellitus

• DOI: 10.1152/ajpregu.00288.2020
• Publication Date: 2021-02-03T13:30:37Z
• Authors: Virginia Pinna; Azzurrra Doneddu; Silvana Roberto; Sara Magnani; Giovanna Ghiani; Gabriele Mulliri; Irene Sanna; Stefano Serra; Seyed Alireza Hos...; Raffaele Milia; Daniela Fadda; Romina Lecis; Marco Guicciardi; Antonio Crisafulli
• Keywords: Impedance cardiography

Cardiovascular regulation is altered by type 2 diabetes mellitus (DM2), producing an abnormal response to muscle metaboreflex. During physical exercise, cerebral blood flow impaired in patients with DM2, and this phenomenon may reduce oxygenation (COX). We hypothesized that the simultaneous execution of a mental task (MT) metaboreflex activation would COX DM2. Thirteen individuals suffering from DM2 (6 women) 13 normal age-matched controls (CTL, 6 participated study. They underwent five different tests, each lasting 12 min: postexercise ischemia (PEMI) activate metaboreflex, control exercise recovery (CER), PEMI + MT, CER MT alone. was evaluated using near-infrared spectroscopy sensors applied forehead. Central hemodynamics assessed impedance cardiography. found when superimposed on PEMI-induced could not increase same extent reached CTL group (101.13% ± 1.08% vs. 104.23% 2.51%, P < 0.05). Moreover, had higher mean pressure systemic vascular resistance as well lower stroke volume cardiac output levels compared group, throughout our experiments. It concluded reduced capacity enhance undertaking during Results also confirm dysregulated exaggerated vasoconstriction. This have implications for these patients' lack inclination exercise.