Influence of acetaminophen and ibuprofen on skeletal muscle adaptations to resistance exercise in older adults

• DOI: 10.1152/ajpregu.00611.2010
• Publication Date: 2010-12-16T05:39:20Z
• Authors: Todd A. Trappe; Chad C. Carroll; Jared M. Dickinson; Jennifer K. LeMoine; Jacob M. Haus; Bridget E. Sullivan; Jonah D. Lee; Bozena Jemiolo; Eileen M. Weinheimer; Chris J. Hollon
• Keywords: Ibuprofen; Acetaminophen

Evidence suggests that consumption of over-the-counter cyclooxygenase (COX) inhibitors may interfere with the positive effects resistance exercise training has on reversing sarcopenia in older adults. This study examined influence acetaminophen or ibuprofen muscle mass and strength during 12 wk knee extensor progressive Thirty-six individuals were randomly assigned to one three groups consumed COX-inhibiting drugs double-blind placebo-controlled fashion: placebo (67 ± 2 yr; n = 12), (64 1 11; 4 g/day), 13; 1.2 g/day). Compliance program (100%) drug (via digital video observation, 94%), intensity similar (P > 0.05) for all groups. Drug unexpectedly increased volume (acetaminophen: 109 14 cm(3), 12.5%; ibuprofen: 84 10 10.9%) 19 kg; kg) a greater extent < than (muscle volume: 69 8.6%; strength: 15 kg), when controlling initial size strength. Follow-up analysis biopsies taken from vastus lateralis before after showed protein content, water myosin heavy chain distribution not influenced by consumption. Similarly, content two known enzymes potentially targeted drugs, COX-1 -2, was consumption, although did result drug-independent increase (32 8%; P 0.05). nonresistance-trained hamstring muscles Over-the-counter doses ibuprofen, combination training, do inhibit appear enhance hypertrophy gains The present findings coupled previous short-term studies provide convincing evidence COX pathway(s) are involved regulation turnover humans.