Cortical activation and lamina terminalis functional connectivity during thirst and drinking in humans

• DOI: 10.1152/ajpregu.00817.2010
• Publication Date: 2011-06-16T18:19:05Z
• Authors: M. J. Farrell; T. K. Bowala; M. Gavrilescu; P. A. Phillips; M. J. McKinley; R. M. McAllen; D. A. Denton; G. F. Egan
• Keywords: Lamina terminalis; Insular cortex; Ventral striatum; Cingulate cortex

The pattern of regional brain activation in humans during thirst associated with dehydration, increased blood osmolality, and decreased volume is not known. Furthermore, there little information available about associations between osmoreceptive regions such as the organum vasculosum lamina terminalis implicated its satiation humans. With objective investigating neuroanatomical correlates dehydration ventral terminalis, this study involved exercise-induced sweating 15 people measures cerebral flow (rCBF) using a functional magnetic resonance imaging technique called pulsed arterial spin labeling. Regional activations thirst, postdrinking were consistent network previously identified systemic hypertonic infusions, thus providing further evidence that monitoring body fluid experience thirst. rCBF measurements correlated whole to identify region. Regions including cingulate cortex, prefrontal striatum, parahippocampus, cerebellum. correlation cortex insula was different for states recent drinking, suggesting connectivity dynamic process influenced by hydration status ingestive behavior.