Fatty acid oxidation and glucose utilization interact to control food intake in rats

• DOI: 10.1152/ajpregu.1986.251.5.r840
• Publication Date: 2017-12-24T12:35:52Z
• Authors: M. I. Friedman; M. G. Tordoff
• Keywords: Carbohydrate Metabolism; Mechanism of Action

To determine whether glucose and fat metabolism interact to control food intake, rats were administered 2-deoxyglucose (2-DG), which inhibits utilization, methyl palmoxirate (MP), fatty acid oxidation. Combined treatment with 2-DG MP increased intake in a synergistic fashion. This effect was observed even at doses of the two agents that alone did not increase it expressed by either an initiation eating or prolonged bout eating, depending on testing conditions. Metabolic measures circulating substrates, liver glycogen, gastric contents confirmed drugs had their intended metabolic effects revealed no evidence one drug enhanced direct action other. The results provide exert coordinated over feeding behavior suggest existence common integrative mechanism control.