Gastric vagus mediates immobilization-induced hypocalcemia in rats

• DOI: 10.1152/ajpregu.1993.265.3.r609
• Publication Date: 2017-12-24T16:02:20Z
• Authors: J. Ma; S. Aou; H. Matsui; T. Hori
• Keywords: Cimetidine; Secretin

The involvement of the parasympathetic nervous system in etiology stress-induced hypocalcemia was investigated rat. Atropine methyl bromide (0.1 and 0.6 mg/kg ip) given 20 min before immobilization (IMB) observed to suppress induction a dose-dependent manner. A vagotomy bilateral cervical trunks also abolished IMB-induced hypocalcemia. on either thyroid/parathyroid branches or celiac had no effect hypocalcemia, but gastric completely it. Pretreatment with secretin (2 6 micrograms/kg ip), an inhibitor gastrin release, cimetidine (5 10 histamine H2-receptor antagonist, diminished concentration serum increased significantly during IMB. It is thus concluded that decreased levels plasma calcium caused by IMB are due activation vagus innervating stomach. Gastrin involved as consequence vagus.