Lateral parabrachial serotonergic mechanisms: angiotensin-induced pressor and drinking responses

• DOI: 10.1152/ajpregu.1995.269.5.r1044
• Publication Date: 2017-12-25T04:39:13Z
• Authors: J. V. Menani; A. K. Johnson
• Keywords: Lateral parabrachial nucleus; Methysergide

This study investigated the effects of bilateral injections serotonergic receptor ligands into lateral parabrachial nucleus (LPBN) on pressor and dipsogenic responses induced by intracerebroventricular (i.c.v.) injection angiotensin II (ANG II). Rats with stainless steel cannulas implanted bilaterally LPBN left ventricle were used to i.c.v. ANG II-induced water intake responses. Pretreatment 5-HT1/5-HT2 antagonist methysergide (1-8 micrograms/200 nl) injected increased (50 ng/microliters) administered via ventricle, but pretreatment (4 did not change response produced II. After either serotonin (5-HT, 5 or 5-HT2a/5-HT2c agonist (+/-)-2,5-dimetoxy-4-iodoamphetamine hydrochloride (DOI; 0.5-10 LPBN, was significantly reduced. These results are consistent Other observations indicating that is associated inhibitory mechanisms controlling treatment suggest pathways may be involved in this effect.