Estrogen influences osmotic secretion of AVP and body water balance in postmenopausal women

• DOI: 10.1152/ajpregu.1998.274.1.r187
• Publication Date: 2017-12-25T01:24:04Z
• Authors: Nina S. Stachenfeld; Loretta Dipietro; Steven F. Palter; Ethan R. Nadel
• Keywords: Hypertonic saline; Plasma osmolality

To determine if estrogen upregulates osmotic secretion of arginine vasopressin (AVP) and alters body water balance, we infused hypertonic (3% NaCl) saline in 6 women (68 ± 3 yr) after 14 days 17β-estradiol (transdermal patch, ∼0.1 mg/day, E 2 ) placebo (control) administration. Hypertonic was at 0.1 ml ⋅ kg −1 min for 120 min, a 30-min equilibration period, the subjects drank ad libitum 180 min. increased basal plasma estradiol concentration from ≤12 to 80 12 pg/ml AVP (P [AVP] 2.1 0.7 3.1 0.8 ( P< 0.05), but not osmolality osm , 288 1 287 1, control respectively). infusion P by 18 17 mosmol/kgH O 5.2 0.5 4.9 0.4 treatments, respectively. The -P relationship shifted upward with no change sensitivity (slope, 0.36 0.02 0.33 0.03 pg mosmol Water intake similar between (24 vs. 22 ml/kg), drinking, urine output free clearance ([Formula: see text]) were reduced 5.6 2.3 ml/kg 2.6 2.0 ml/min, respectively < 0.05) . Plasma aldosterone unaffected fractional sodium excretion 2.7 1.7 0.4% drinking. Our data suggest that augments secretion, thereby implicating elevated as contributor retention high states; however, an increase renal reabsorption major component enhanced fluid retention.